Friday, April 4, 2008

Four Ways To Grow Your Subscriber List

If you publish your own newsletter or ezine, you are always on the lookout for more quality subscribers. We all continuously look for new sources to grab a few more subscribers. Today, I am going to look at a four ways that you can add to your list.1. Ezine Directories - One way to get your ezine some exposer and also pick up a few subscribers, is to submit to ezine directories. Some of these also give you a chance to list your advertising information as well. Here are a group of directories that you can submit to.http://paml.net/submissions.htmlhttp://catalog.com/vivian/intsubform2.html http://www.diysearch.com/ http://www.ezinesearch.com/search-it/ezine/ezine-add.html http://www.newsletteraccess.com/database/reg.html http://ezineadsource.com/submit.htm http://ezine-universe.com http://www.ezinehub.com/add.html http://newz2me.com http://www.homebizandmore.homestead.com/ezinesignup.html 2. Pay Per Subscriber Services - If you would like to build your list quickly and have the funds, this is the way. These are services that will provide you with subscribers at a certain price for each subscriber. There are quite a few of these services and they sign up subscribers for you in a number of ways. They use everything from pop-ups to pay-per-click search engines to get subscribers for you. Each one is different. Ask how they get their subscribers and my own personal preference would be to have them double opt-in the subscribers. This will usually get you a better quality of subscriber. Here is a list of some of those services.http://www.listopt.com http://www.itsaworld.net http://www.zmedia.com/zm/main.html http://www.funezines.com http://www.bay9.com http://www.profitinfo.com 3. Subscribers for Ads - There are a few services that will provide you with subscribers for running an ad for that subscriber. If you run free ads, these services can provide you with quite a few new subscribers each month. Here are a few of those services.http://www.moneyforhire.com/inet http://www.ads4subs.com http://www.twodollarads.com 4. Ad Swaps - This way of getting subscribers is overlooked too often or not used for some reason. Take the time and put forth the effort to exchange ads with other ezines. You can advertise for new subscribers in many other ezines by exchanging ads. You are not going to get thousands of subscribers this way but if you swap ads with a few different ezines every month or even every week, you will see a steady flow of new subscribers. These are not the only ways to generate new subscribers but if you start using some of these methods, you will see your subscriber list start to grow.

Generate More Traffic

There are many new traffic exchange sites that have popped up in the last few months. I personally use quite a few of them and generate an average of 200 hits a day from them. It is not something that happens overnight but if you start signing up some people in a few of these programs, you will reap the benefits of your effort. There are many to choose from and for those of you who use them, I am sure you have your favorites. There are some that will provide you with a lot of hits but what you are looking for is quality hits. You are looking for the ones that actually bring you traffic that will respond to whatever it is you are offering. I personally also like to use a rotator service to send my traffic to different sites that I have. There are free rotators out there, though most that I have used are not of the quality of eBiz Rotator. You can join free and rotate three sites, but I personally use the upgraded service that costs $48 for six months. For eight dollars a month, you can not only rotate up to 10 sites, you can also advertise another ten on your portfolio page. They also offer an affiliate program and building a downline in it has been quite easy. By rotating your sites, you can build a nice downline in several programs and still advertise your products and website as well. This system works very well to start building traffic. Here is my eBiz Rotator site in case you would like to check it out. http://www.ebizrotator.com/goto/RJ1550.htm I would also urge you to join as many of the traffic generator sites as possible. The more of these programs that you can start building a downline in, the more traffic you will see in the future. I, like most of you, have my favorites of these programs. I think you will find that some just bring a higher quality of visitor. Here are three that have given me a lot of visitors and I have been pleased with the quality.AdSwappers - This is one that I just joined a few weeks back but is already a favorite. The quality of visitors from this site has been very good to this point. You can check it out here.http://www.adswappers.com/index.cgi?refid=braveone TrafficJumbo - This one has generated 3,000 hits for me in a month and a half. You get 150 hits for each person that joins under you. You also receive one hit for every four times that your downline generates a hit. This helps generate traffic very quickly. You can check it out at http://www.jado.org tintro.php?referrerid=288 HitPulse - This is one that I actually did not care much for until recently. They have made a lot of changes and I am now getting some nice traffic from them. You can check them out athttp://www.hitpulse.com/cgi-bin/start/newuser.cgi?referer=braveone As I said before, join as many as you can, start building a downline and you will start to see your traffic grow. Here is a list of some others that you might try as well. http://www.startblaze.com/cgi-bin/intro.cgi?60899 http://www.clicksilo.com/referrals/info.asp?Agent=braveone http://nomorehits.com/cgi-bin/start.cgi?referrer=braveone http://www.hitshammer.com/hh/start.cgi?braveone http://www.clickthru.net/referral?ref=291941 http://ultimatetrafficsystem.com/?10537 http://www.ezfree.net/free/users/braveon.shtml http://adsplit.com/?braveone http://www.wildfireco-op.net/a.asp?70041684

Sanity? Are you kidding

Do you have what it takes to be an ezine publisher? Someone told me the other day that anyone could become a newsletter or ezine publisher. That put me into some deep thought about the situation. I decided that it was probably true that anyone could become a publisher of an ezine or newsletter. The trick is to publish one that is successful and still keep one's sanity. Sanity you ask? How could I possibly lose my sanity putting out an issue of a newsletter or ezine? Well my good friend, let me help you count the ways. Right after I first started publishing, I had the chance to go up to a mountain lake with some friends one evening. I actually needed to get my ezine out but I thought what the heck, I will get up a few hours early tomorrow morning and finish putting it together. Wrong unwise one. The next morning when I got up my electricity was off. I waited quite impatiently as I watched the hours tick away. My wife had a doctor's appointment that afternoon, so I had to leave to take her to town. She had been unable to drive for the last few months due to destroyed ligaments in her foot. I tried to not think about it as I took her to town. Of course when we finished at the doctor's office, she insisted that I take her out to eat. Well, if you think there was any way that I could say no to that one, you obviously don't have a wife. Or you won't have one for long. We arrived back home late in the afternoon. I was thrilled to find that the electricity was working again. I started putting together my issue of the ezine. I went to connect to the internet to send it out and could not hook up to my ISP. I got on the phone and called my ISP and was told that they were having problems of some sort and were not sure when service would be restored. By this time it was getting on up in the evening and all at once the realization came that I should already have tomorrow's issue ready and yet I had not even started. This was far from comforting. So I started putting tomorrow's issue together. I had just started working on it when my wife hollered and asked me if I was going to work all night. That's right I thought, I promised her that I would spend some time with her this evening. After spending a couple of hours with my wife, I started working on the ezine again. I worked until about 2:00 AM. I finally finished and went up to get a few hours sleep before I had to get back up. About 3:30 I was startled out of bed by what appeared to be a loud scream. I started running towards my wife's bedroom when here came that startling sound again. It was my Tom Cat. He was ready to go outside. Oh I could ignore him but if you know anything about Tom Cats, that would have only punished myself more. I went back to bed only to be awaken by a cat fight around 4:45. The Tom from the next valley over had came over to pay us a friendly visit. Of course his idea of a friendly visit was to come over and see if he could kill my cat. Well my cat had not made any brownie points by waking me up earlier but if I did not go rescue him, I would be in the dog house with my wife. This would never work because the only pet facility that we had was a small cat palace and I already had a backache. To heck with trying to sleep. I went to check and see if my ISP was back up. Great, I was back in business. I first sent out yesterday's issue and then put the finishing touches on today's. I then sent it out as well.I then decided to go check my mail and make sure I received both issues. I looked at the first issue and I had forgotten to put the right address in the Title. Instead of my first name, which will show if I type the following [FIRSTNAME], I saw [FIRSTNAME. I had forgot to close my parenthesis and everyone's ezine came out addressed to [FIRSTNAME. I then took a look at today's issue. I had typed in the wrong date on the top, I had forgotten to put contact information in my ad for a advertising special. I was not feeling real good about myself at this point. I then looked back at my mail and saw a note addressed to me with suggestion as the subject. I thought, to heck with reading that. After the last two days, they are probably suggesting that I take a permanent vacation. I just don't know if I can take that kind of rejection right now. I need sleep. I headed up to bed and passed my wife who was heading down the steps. She asked if I was going up to change into work clothes. My mind started churning, what had I promised to do this morning? She brought me out of my thought by informing me that she would do the inside of the windows while I did the outside. Sanity? That has long since passed me by. So back to the question, can anyone publish an ezine? Well if the subscriber who sent me the suggestion is anywhere close to correct, I am not qualified to answer. Here is his suggestion. You could not publish a #$%&*%$ ezine if your ^$##@*%#* life depended on it. I also got brave and told my wife that I don't do windows. I am now trying to get some of the sleep that my body so desperately needs but the accommodations seem less than cozy. This cat palace is sure not the luxurious place that I had been led to believe. Honey, I was just kidding, I will gladly help with those windows.

Profit From Reading

A while back my youngest son came to visit for a few days. He and his family arrived late one night and after visiting for a couple of hours, we all turned in. The next morning when he came down for his caffeine jump start, I was sitting at my desk with my computer on. This is my normal daily routine. I start my day around four, yes that's four in the morning unlike my son who is usually going to bed about that time. Anyway, he just mumbled good morning and took his coffee and headed out to sit by the lake. The second morning, he looked at me very strangely as he went by. Finally on the third morning he asked me what I could possibly be accomplishing sitting there staring at the screen for so many hours? When I told him that I was reading, I got another shake of the head and off he went. Do you spend much of your day reading? If you are part of the internet marketing world and you answered no, you are making a big mistake.What do I read? I subscribe to and read an amazing number of ezines. I know that most of you just use them to get your free ads and don't even pay attention to any of the content. If you want to succeed in the internet marketing field, I urge you to subscribe to ezines. Read the content and find which one's provide you with quality material. Keep subscribing to those you find useful and discard the one's that don't. Then go out and subscribe to some more and repeat this process. If you spend all of your time sending out free ads to ezines and FFA sites instead of reading, you have your priorities in the wrong order. I was reading an article on advertising the other day. The author stated that research was a big step in writing good ad copy. Well. I am here to tell you that reading is a big part of being successful in the marketing world. I read ezines, I read books, I read news articles and I could go on and on. I read everything that might have an influence on the internet marketing industry. Ninety to ninety five percent of the people who are trying to work in the internet marketing field are going about it all wrong. They are spending their time unwisely and will be in the same circumstances a year from now. Most of you who are trying to work on the internet have a limited number of hours each week to put towards your marketing business. I strongly urge you to allot some of that time to reading. If you do this consistently for a few weeks, you will be amazed at what you learn

Saturday, March 15, 2008

Alosetron:

U.S. BRAND NAMES — Lotronex®
PHARMACOLOGIC CATEGORY Selective 5-HT3 Receptor Antagonist
DOSING: ADULTS — IBS: Female: Oral: Initial: 0.5 mg twice daily for 4 weeks, with or without food; if tolerated, but response is inadequate, may be increased after 4 weeks to 1 mg twice daily. If response is inadequate after 4 weeks of 1 mg twice-daily dosing, discontinue treatment. Note: Discontinue immediately if constipation or signs/symptoms of ischemic colitis occur. Do not reinitiate in patients who develop ischemic colitis.
DOSING: PEDIATRIC — Safety and efficacy have not been established.
DOSING: ELDERLY — Refer to adult dosing. Dosage adjustment is not required; however, postmarketing experience suggests that elderly patients may be at greater risk for complications of constipation.
DOSING: RENAL IMPAIRMENT — The need for dosage adjustment has not been defined (due to limited information on activity of metabolites).
DOSING: HEPATIC IMPAIRMENT — In mild-to-moderate dysfunction (Child-Pugh score 9), use caution. Avoid use in severe hepatic dysfunction (Child-Pugh score >9).
DOSAGE FORMS — Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Tablet: 0.5 mg, 1 mg
DOSAGE FORMS: CONCISE Tablet: Lotronex®: 0.5 mg, 1 mg
GENERIC EQUIVALENT AVAILABLE — No
ADMINISTRATION — May be administered with or with food; however, absorption may be reduced by approximately 25%.
USE — Treatment of women with severe diarrhea-predominant irritable bowel syndrome (IBS) who have failed to respond to conventional therapy
ADVERSE REACTIONS SIGNIFICANT >10%: Gastrointestinal: Constipation (dose related) (29%)
1% to 10%: Gastrointestinal: Abdominal discomfort and pain (7%), nausea (6%), gastrointestinal discomfort and pain (6%), abdominal distention (2%), hemorrhoids (2%), regurgitation and reflux (2%)
<1% (Limited to important or life-threatening): Allergic skin reactions, anxiety, bilirubin level changes, bladder inflammation, bone pain, breathing disorder, cholecystitis, cognitive function disorders, confusion, cramps, colitis, depression, diaphoresis, diverticulitis, dyspepsia symptoms, fatigue, gastroenteritis, GI lesions, GI motility decreased, GI obstructions, GI spasms, headache, hemorrhage, hepatitis, hyperacidity, hyper-/hypoglycemia, hypertension, hypnagogic effects, hypoesthesia, hypothalamus/pituitary dysfunction, ileus, impaction, ischemic colitis, memory effects, muscle pain/stiffness, obstruction, occult stools, pain, perforation, rash, RBC/hemoglobin defects, sedation, sexual dysfunction, skeletal pain, small bowel mesenteric ischemia, tachyarrhythmia, temperature regulation impairment, tremor, ulceration, ulcerative colitis, urinary frequency, urticaria
CONTRAINDICATIONS — Do not start treatment in patients who are constipated. Hypersensitivity to alosetron or any component of the formulation; history of severe or chronic constipation; history of ischemic colitis, intestinal obstruction, stricture, toxic megacolon, gastrointestinal perforation and/or adhesions; active diverticulitis, current or history of Crohn's disease, severe hepatic dysfunction, or ulcerative colitis; history of impaired intestinal circulation, thrombophlebitis, or hypercoagulable state; patients unable to understand or comply with "Patient-Physician" agreement; concomitant administration with fluvoxamine
WARNINGS / PRECAUTIONS Box warnings: Constipation: See "Concerns related to adverse effects" below. Ischemic colitis: See "Concerns related to adverse effects" below. Patient-Physician agreement: See "Other warnings/precautions" below.
Concerns related to adverse effects: Constipation: [U.S. Boxed Warning]: Discontinue immediately in patients with constipation. Constipation is a frequent, dose-related side effect; serious complications of constipation have been infrequently reported (obstruction, perforation, impaction, toxic megacolon, secondary ischemia); risk may be increased in elderly, debilitated patients, or with concurrent use of other medications which decrease GI motility. Nonsevere constipation may be managed by temporarily interrupting therapy. Ischemic colitis: [U.S. Boxed Warning]: Acute ischemic colitis has been reported during treatment. Discontinue immediately in patients who experience rectal bleeding or a sudden worsening of abdominal pain, and do not restart therapy if ischemic colitis is diagnosed.
Disease-related concerns: Hepatic impairment: Use caution in mild-to-moderate hepatic impairment (Child-Pugh score 9); do not use in severe impairment (Child-Pugh score 10).
Special populations: Males: Safety and efficacy have not been established in males. Pediatrics: Safety and efficacy have not been established in children.
Other warnings/precautions: Patient-Physician agreement: [U.S. Boxed Warning]: Patients must read and sign a "Patient-Physician" agreement before receiving the initial prescription.
RESTRICTIONS — Only physicians enrolled in GlaxoSmithKline's Prescribing Program for Lotronex® may prescribe this medication. Program stickers must be affixed to all prescriptions; no phone, fax, or computerized prescriptions are permitted with this program.
An FDA-approved medication guide must be distributed when dispensing an outpatient prescription (new or refill) where this medication is to be used without direct supervision of a healthcare provider. Medication guides are available at http://www.fda.gov/cder/Offices/ODS/medication_guides.htm.
DRUG INTERACTIONS — Substrate of CYP1A2 (major), 2C9 (minor), 3A4 (minor); Inhibits CYP1A2 (weak), 2E1 (weak)
CYP1A2 inhibitors: May increase the levels/effects of alosetron. Example inhibitors include ciprofloxacin, fluvoxamine, ketoconazole, norfloxacin, ofloxacin, and rofecoxib.
Fluvoxamine: Concomitant use is contraindicated.
ETHANOL / NUTRITION / HERB INTERACTIONS — Food: When administered with food, absorption may be reduced by ~25%.
PREGNANCY RISK FACTOR — B (show table)
PREGNANCY IMPLICATIONS — There are no adequate and well-controlled studies in pregnant women. Alosetron should be used in pregnant women only if clearly needed.
LACTATION — Excretion in breast milk unknown/use caution
BREAST-FEEDING CONSIDERATIONS — Animal studies indicate that alosetron and/or metabolites are excreted in breast milk. It is not known if alosetron in excreted in human milk. Caution should be used in administering alosetron to a nursing woman.
DIETARY CONSIDERATIONS — May be taken with or without food.
PRICING — (data from drugstore.com)Tablets (Lotronex) 0.5 mg (30): $252.47
MECHANISM OF ACTION — Alosetron is a potent and selective antagonist of a subtype of the serotonin 5-HT3 receptor. 5-HT3 receptors are ligand-gated ion channels extensively distributed on enteric neurons in the human gastrointestinal tract, as well as other peripheral and central locations. Activation of these channels affect the regulation of visceral pain, colonic transit, and gastrointestinal secretions. In patients with irritable bowel syndrome, blockade of these channels may reduce pain, abdominal discomfort, urgency, and diarrhea.
PHARMACODYNAMICS / KINETICS Distribution: Vd: 65-95 L
Protein binding: 82%
Metabolism: Extensive hepatic metabolism. Alosetron is metabolized by CYP2C9, 3A4, and 1A2. Thirteen metabolites have been detected in the urine. Biological activity of these metabolites in unknown.
Bioavailability: Mean: 50% to 60% (range: 30% to >90%); decreased with food (25%)
Half-life elimination: 1.5 hours for alosetron
Time to peak: 1 hour after oral administration
Excretion: Urine (73%) and feces (24%); 7% as unchanged drug (1% feces, 6% urine)
PATIENT INFORMATION — Take with or without food. Do not take if you are frequently constipated; constipation is a side effect associated with this medication and can lead to serious complications. Stop taking this medication and call your prescriber if you become constipated, or if you have sudden worsening of abdominal pain, severe constipation, or blood in your stool. Do not continue taking the medication until you have spoken with your prescriber; if after stopping the medication, constipation does not resolve, call your prescriber again. Notify your prescriber if you are pregnant, plan on becoming pregnant, or if you are breast-feeding.