ZANTAC Glaxo SmithKline
Drug Category: H2 blocker.
Generic Name: Ranitidine.
Contents: Inj: Per 2ml amp: 50mg ranitidine (as HCI).
Tabs 150mg/300mg: 150mg/300mg ranitidine (as HCI).
Indications: Treatment of duodenal, benign gastric and post-operative ulceration, including that due to NSAIDs. Prevention of NSAID induced duodenal ulcers. Duodenal ulcers associated with H. pylori. Oesophageal reflux, reduction of gastric acid, chronic episodic dyspepsia. Moderate to severe oesophagitis.
Dosage: Tabs: Adults: Duodenal and gastric ulcer: 150mg twice daily or 300mg at bedtime for four weeks or 300mg twice daily; maintenance, 150mg at bedtime.
DU with H. pylork 300mg at bedtime for 4 weeks plus amoxycillin 750mg three times daily and metronidazole 500mg three times daily for 2 weeks. Prevention of NSAID Induced duodenal ulcer: 150mg twice daily.
Reflux oesophagitis: 150mg twice daily or 300mg at bedtime for up to 12 weeks. If moderate to severe, 150mg four times daily for up to 12 weeks.
Children: Under 2 years, not recommended; over 2 years, peptic ulceration only. 2-4mg/kg twice daily; max 300mg daily.
Inj: Adults: Slow (over a period of 2 mins) IV inj of 50mg after dilution to a volume of 20ml per 50mg dose; intermittent IV infusion at a rate of 25mg per hour for 2 hours; IM in] of 50mg (2ml). All may be repeated every 6-8 hours.
Precautions: Exclude malignant disease before treatment. Impaired renal function, acute porphy-ria. Pregnancy, lactation.
Adverse effects: Headache, dizziness, Changes in liver function. Rarely hepatitis, thrombocytopenia. leucopenia, agranulocytosis, pancytopenia, hy-persensitivity, confusion, breast symptoms in men, reversible impotence, rash. bradycardia, pancreatitis.
Regn.No:Pack:Trade Prices:Retail Prices:
lnj(008626):5x2ml amp: 93.98:110.56.
Tabs 150mg(006520):10's: 74.97:88.20.
Tabs 300mg(022034):10's: 151.29:177.98.
